MOC 5001 : Advanced Organic Chemistry (3C)

MOC 5001 : Advanced Organic Chemistry (45L) - 3 credits

Mechanistic & stereochemical approach to organic reactions (11 L) 

Reactions of organic compounds as acids and bases, Reaction pathways, Conformational analysis, Overview of stereochemistry, Nucleophilic substitution and elimination reactions, Nucleophilic addition to carbonyls, Nucleophilic substitution of carboxylic acid derivatives, Enols and enolate anions as nucleophiles, Electrophilic substitution of aromatic compounds, Chemistry of amines, Oxidation and reductions.

Organic synthesis (12 L)

Retrosynthetic analysis, Simple examples of retrosynthetic analysis with C-C bond disconnections, Synthesis of alkenes, Two-group disconnections: 1,3-Dioxygenated skeletons, 1,5-Dicarbonyl compounds, “Illogical” two group disconnections: 1,2-Dioxygenation pattern, 1,4-Dioxygenation pattern, Analysis of 1,6-Dicarbonyl compounds, Disconnections of heterocyclic compounds, Synthesis of 3- and 4-membered rings, Use of protecting groups in organic synthesis, Examples of total synthesis & asymmetric synthesis.

Heterocyclic chemistry (06 L)

Nomenclature, Aromatic heterocyclic compounds, Reactions of heterocycles as acids and bases, Synthesis of heterocycles by reaction of nucleophiles with carbonyls compounds, Substitution reactions of heterocyclic compounds: Pyrimidines, purines, pyridines and five membered heterocycles and their biological significance.

Concerted reactions (06 L)

Overview of concerted reactions, Cycloaddition reactions of carbons compounds: Electrocyclic reactions, 1,3-dipolar additions and sigmatropic rearrangements, Reactions of carbenes.

Industrial organic synthesis (06 L)

Introduction to organometallic chemistry, Basic products of industrial synthesis: Synthesis gas: Generation, purification and applications, Pure synthesis gas components: Generation, purification and applications, C1 units: Manufacture and applications of methanol, formaldehyde etc.

Synthesis and fabrication of organic nanomaterials (04 L)

Introduction to organic nanomaterials, synthesis, characterization using Scanning Electron Microscopy (SEM)/Transmission Electron Microscopy (TEM)/ Atomic Force Microscopy (AFM).